Where are the intelligent beings in the universe? I have one thought, but I will have to carefully lay out the pieces of the puzzle in front of you in order to put everything together at the very end. So I ask for a little patience.
Competition
Communities of people often compete with each other - with clubs, vigorous bombs, or industrial espionage. On the other hand, a person does not compete at all, for example, with hedgehogs. We have nothing to compete with them for - we have too different niches. But hedgehogs are too extreme an example, let's look at the example of two human societies - we will change the 'distance' between them in the level of development, and see what happens.
With equal development, we will get fierce competition. Let's slightly unscrew the tuning hand, sending one of the societies 'into the past'. This is a typical colony-metropolis relationship. Exploitation, but also progressorship.
Now let's turn the handle harder and get the non-contact tribes :
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So, after our Mind Upload and going to the Moon, civilization will be thrown back - only the most primitive and stubborn groups will cling to their biological existence. For a while, they will have strange traces of very high technology, inappropriate to their development, which faded over time. And after a while, only megaliths and inappropriate artifacts remind of us to a new, rapidly developing humanity v2.0
Although ... such a world seems very familiar to us. Where did we get that we are Humanity v1.0?