You may have heard the saying: "Lord, take away everything, just do not deprive your mind." But, unfortunately, everyone's old age is different, and often, in order not to suffer remorse later, it is necessary to choose it almost from childhood. And the saddest thing is that our society has somehow got used to the stereotype of “dull old people”. Few people know that under senile dementia, or, more simply, marasmus, or age-related dementia, there are quite real diseases. Often, the one whom we call a crazy old man is just a sick person who was abandoned by society even when he could be saved. How not to turn into a monster and not go crazy in retirement?
Alzheimer's, Parkinson's and Pick's disease. Welcome to one of the Riders of Insanity series posts on ScientaeVulgaris.
, , , , , . () . , , . , , , . - , , , .
, , - , , . . , , . , , , . , , , , 60 «», . , , , , .
, , - , . , , , - , , . , , . -, , 5 «», 10- , 4- , . « » :
«, ! , , - , , , , , , , , , , … … , - , , , , , , , , …»
, , , . , , , , . . 2500 , « », , , , , , , , , , , , , , , ( « »). , , , , , .
, . , « » , - , - . , . , , , .
17- . , « », . , . « , - ». , , . , . - , , , .
« » . , , , , , .
: " ."
. - ( .). , , « ». , 50, 1890- ., : , , . , , , . 25 1901 , , , « » , ( ).
90 . 32 3 , 1 2 . , , , . ., , . 4 , , .
.
26 1901
. - ? - . ? - . - ? - . - ? - . - ? - ... .
, . - ? - . - .? - , , . - ?
, . - . - ? ( ). - .
, , . . , , - "". , , , - " ". , , . , - . - , , , . ., . ...
29 1901
... - ? - 1800-. - ? - . - ? ( ). - ? - . - ? - , . - ? - . ... - 6 70 , ? - -.
- ? - , . - ? - . - ? - , , ... - ? - . . . - ? - , .
7 1905 , 8 1906 - .
- Ich habe mich verloren. - « ». , , , . 13 . 41, 55. 20- . PSEN1, , - ... .
?
, , . , : , 2- , , , . . , 8 , , . . , , . ?
8. : . ? , . .
. , , . , . . . . . , .
, , , , , ( ), ( , ). , , ( ), ( , ). , , , , . , - . - , , . , , .
?
. , , . . , . , , - , , , . , , , -... . , , - .
.
, , , . . Proceedings of the National Academy of Sciences , - . . - , . - , . , . . . , .
. - , . , , , ? . , .
, - - , . . . 42 (Aβ42). - . , , . , . . -.
, , , , , . , . , , . -. , , , , . - , . , . «»: - , . , - . , .. , . - -. :
Aβ42 ( - ) . - . , , , , , . , .
"" :
( - , - ):
, , , . - , -, - . , , , , . , - , .
, , , . , , . - , . , - , , , .
, , 60- - - , , , , - , / . , - … ( ), , 2004 ( , p. 6.11.14.) and since then around the world, there has been a steady increase in the number of cases, with the expectation of an increase of up to 300-500% by 2050 from the current figures. In the United States, for example, the number of patients today is estimated at almost 6 million people, and in the world - more than 44 million.
https://www.scientaevulgaris.com/