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First COVID-19 vaccines. Comparison of Russia's Sputnik V and Pfizer's BNT162b2

On November 9, the American pharmaceutical giant - Pfizer announced the successful completion of the third phase of clinical trials of the BNT162b2 vaccine against the new coronavirus, and the results obtained are 90% effective.

It is curious that just 2 days after the Pfizer press release, the website of the Russian Sputnik V vaccine (named after the prototype ship that sent the first man into space) published a message about its 92% effectiveness.

In this article, we will compare these two vaccines, analyze how they work, and also talk about why the world scientific community was quite critical of the Russian vaccine.

Content:

  1. Comparison of preliminary results of the third phase

  2. How immunity to viruses appears

  3. Types of modern vaccines

  4. How Sputnik V vaccine works

  5. What is the difference between a vaccine and Pfizer

  6. Outcome

Comparison of preliminary results of the third phase of clinical trials

, - BNT162b2, Pfizer BioNTech, 43 , 90% .

, 94 COVID-19 , , 90% , . ā€” 7 . 38 . ā€” 14 , [1].

Source: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against
: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against

Ā« VĀ» 92% , COVID-19 16 21 , 20 [2].

Ā« VĀ» , 3- [3], , , 20 . , [4].

Source: https://sputnikvaccine.com/rus/newsroom/pressreleases/effektivnost-vaktsiny-sputnik-v-protiv-koronavirusa-sostavila-92-v-khode-pervogo-promezhutochnogo-an/
: https://sputnikvaccine.com/rus/newsroom/pressreleases/effektivnost-vaktsiny-sputnik-v-protiv-koronavirusa-sostavila-92-v-khode-pervogo-promezhutochnogo-an/

, . , , "" .

, ā€” ( ) [5].

, , , ā€” . , - ā€” , - .

: B- ( Bone marrow ā€” ) - ( Thymus ā€” ). , - , , ā€” - . - () - (-), ā€” , .

- -, , ā€” , - , , - , , , , .

ā€” , , .

:

, , . , , . :

  • ā€” , ā€” ā€” . , , MMR ā€” , . .

  • ā€” ā€” , , ā€” , , [6].

  • ā€” , . , , ā€” , , [7].

Ā« VĀ»

Ā«--Ā» Ā« VĀ» . , : ā€” -, , , , .

Ā« VĀ», . . . Sars-COV-2, (spike protein), .

: , , , - , -, [8].

Source: https://www.gamaleya.org/research/vaktsina-protiv-covid-19/
: https://www.gamaleya.org/research/vaktsina-protiv-covid-19/

Pfizer

BNT162b2 Pfizer BioNTech , ā€œā€ Ā« VĀ» .

BioNTech , , () , - [9].

BioNTech . Sars-COV-2 , Ā« VĀ» BNT162b2 ā€” .

BNT162b2 Ā« VĀ» , .

. Ā« VĀ» [3] [4].

:

, , , .

, , Ā« Ā», , .

1 https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against

2 https://sputnikvaccine.com/rus/newsroom/pressreleases/effektivnost-vaktsiny-sputnik-v-protiv-koronavirusa-sostavila-92-v-khode-pervogo-promezhutochnogo-an/

3 https://www.nature.com/articles/d41586-020-02386-2

4 https://www.nature.com/articles/d41586-020-03209-0

5 https://www.ncbi.nlm.nih.gov/books/NBK27140/#A449 6 https://www.niaid.nih.gov/research/vaccine-adjuvants

7 https://www.niaid.nih.gov/research/vaccine-types

8 https://www.gamaleya.org/research/vaktsina-protiv-covid-19/

9 https://biontech.de/covid-19



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