TLDR (translator's note): On September 4, Russian scientists published the results of the 1st and 2nd phases of the study of the Russian Sputnik V vaccine against SARS-CoV-2. In response to the publication of the article, 22 scientists signed an open letter to the editors of the journal and the authors of the article, in which they doubted the reliability of the data presented. In the provided results, a correlation was repeatedly found between the results of independent experiments, including complete coincidence of analyzes and coincidence of measurements with an accuracy of 2x in two independent groups of volunteers.The evidence indicated in the letter indicates an error in the preparation of the article or deliberate falsification of data. Scientists asked the authors of the article to provide raw data for detailed analysis. The Lancet magazine passed the contents of the letter to the authors of the article and invited them to participate in the scientific discussion. Russian scientists have publicly refused to respond to criticism, stating that the data presented in the article is reliable and accurate.
This is an open letter to Denis Logunov and other authors of the article:
Lancet. 2020; 0 (0). doi: 10.1016 / S0140-6736 (20) 31866-3
and Richard Horton (editor of The Lancet).
The article presents the results of a phase 1/2 study of an adenovirus-based vaccine using vectors Ad5 and Ad26 for the SARS-CoV-2 spike proteins as an antigen, presented in two states - liquid and dry freezing.
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Prof. Enrico Bucci – Temple University ()
Dr. Joseph Bertolini – Retired ()
Prof. Raffaele Calogero – Turin University ()
Prof. Ernesto Carafoli – VIMM ()
Dr. Piero Carninci – RIKEN Center for Integrative Medical Sciences ()
Eng. Silvano Coletti, Chelonia SA ()
Prof. Pellegrino Conte – Palermo University ()
Prof. Andrea Cossarizza – University of Modena and Reggio Emilia ()
Prof. Michele De Luca – University of Modena and Reggio Emilia ()
Dr. Andrea Grignolio – CNR ()
Dr. Matthias Goerlach – Leibniz Institute on Aging-Fritz Lipmann Institute ()
Prof. Samir Kabbabe – Hospital Universitario de Caracas ()
Prof. Luigi Marchionni – Weill-Cornell Medicine ()
Prof. Valentina Massa – Milan University ()
Prof. Cristina Mussini – University of Modena and Reggio Emilia ()
Prof. Angelo Parini – INSERM ()
Prof. Gianluca Sbardella – Salerno University ()
Dr. Teresa Stocki – Leeds Teaching Hospitals NHS Trust ()
Prof. Loretta Tuosto – Rome University “La Sapienza” ()
Prof. Antonella Viola – Università degli studi di Padova ()
Dr. James Watson – Mahidol University ()
Dr. Stefano Zona – Dept. of primary care AUSL Modena ()
, , : bucci@shro.org
The Lancet
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The published data are reliable and accurate and have been reviewed by five reviewers of The Lancet , and a full-length clinical protocol was provided to the editorial office of the journal.
We presented exactly the data that we received, and not the ones that Italian experts should like. "